Antiproliferative effects of mesenchymal stem cells carrying Newcastle disease virus and Lactobacillus Casei extract on CT26 Cell line: synergistic effects in cancer therapy.
Akbar Ghorbani AlvaneghMajid Mirzaei NodooshanRuhollah DorostkarReza RanjbarBahman Jalali KondoriAlireza ShahriaryKarim ParastoueiSoheil VazifedustElmira AfrasiabHadi Esmaeili Gouvarchin GhalehPublished in: Infectious agents and cancer (2023)
The results suggest that MSCs carrying oncolytic NDV in combination with L. casei extract as a potentially effective strategy for cancer immunotherapy by promoting the generation of LDH, ROS, and apoptosis in the microenvironment of the CT26 cell line.
Keyphrases
- disease virus
- cancer therapy
- mesenchymal stem cells
- oxidative stress
- image quality
- dual energy
- computed tomography
- umbilical cord
- contrast enhanced
- cell death
- drug delivery
- dna damage
- stem cells
- anti inflammatory
- endoplasmic reticulum stress
- positron emission tomography
- bone marrow
- magnetic resonance imaging
- cell cycle arrest
- reactive oxygen species
- cell therapy
- pet ct