Comprehensive real time remote monitoring for Parkinson's disease using Quantitative DigitoGraphy.
Shannon L HoffmanPaul SchmiedmayerAryaman S GalaKevin B WilkinsLaura ParisiShreesh KarjagiAarushi S NegiSimon RevlockChristopher CorizJeremy RevlockVishnu RaviHelen M Bronte-StewartPublished in: NPJ Parkinson's disease (2024)
People with Parkinson's disease (PWP) face critical challenges, including lack of access to neurological care, inadequate measurement and communication of motor symptoms, and suboptimal medication management and compliance. We have developed QDG-Care: a comprehensive connected care platform for Parkinson's disease (PD) that delivers validated, quantitative metrics of all motor signs in PD in real time, monitors the effects of adjusting therapy and medication adherence and is accessible in the electronic health record. In this article, we describe the design and engineering of all components of QDG-Care, including the development and utility of the QDG Mobility and Tremor Severity Scores. We present the preliminary results and insights from an at-home trial using QDG-Care. QDG technology has enormous potential to improve access to, equity of, and quality of care for PWP, and improve compliance with complex time-critical medication regimens. It will enable rapid "Go-NoGo" decisions for new therapeutics by providing high-resolution data that require fewer participants at lower cost and allow more diverse recruitment.
Keyphrases
- healthcare
- palliative care
- quality improvement
- high resolution
- electronic health record
- affordable care act
- pain management
- clinical trial
- stem cells
- randomized controlled trial
- emergency department
- high throughput
- health insurance
- deep learning
- parkinson disease
- artificial intelligence
- sleep quality
- brain injury
- phase ii
- subarachnoid hemorrhage
- cell therapy
- single cell
- big data
- open label
- cerebral ischemia
- data analysis