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Recombinant truncated latency-associated peptide alleviates liver fibrosis in vitro and in vivo via inhibition of TGF-β/Smad pathway.

Xudong SongJiayi ShiJieting LiuYong LiuYang YuYufei QiuZhiqin CaoYu PanXiaohuan YuanYanhui ChuDan Wu
Published in: Molecular medicine (Cambridge, Mass.) (2022)
LAP and tLAP could alleviate liver fibrosis in vitro and in vivo via inhibition of TGF-β/Smad pathway. TLAP has higher expression level and more effective anti-fibrosis activity compared to LAP. This study may provide new ideas for the treatment of liver fibrosis.
Keyphrases
  • liver fibrosis
  • transforming growth factor
  • epithelial mesenchymal transition
  • poor prognosis
  • mouse model
  • signaling pathway
  • combination therapy
  • cell free