Molecular magnetic resonance imaging of myeloperoxidase activity identifies culprit lesions and predicts future atherothrombosis.
James NadelXiaoying WangPrakash SahaAndré BongersSergey TumanovNicola GiannottiWeiyu ChenNiv VigderMohammed M ChowdhuryGastao Lima da CruzCarlos VelascoClaudia PrietoAndrew JabbourRené M BotnarRoland StockerAlkystis PhinikaridouPublished in: European heart journal. Imaging methods and practice (2024)
We show that elevated intraplaque MPO activity detected by molecular MRI employing MPO-Gd predicts future atherothrombosis in a rabbit model and detects ruptured human atheroma, strengthening the translational potential of this approach to prospectively detect high-risk atherosclerosis.