LAT1 expression influences Paneth cell number and tumor development in Apc Min/+ mice.

Yunlong SuiNamiko HoshiRyuichi OhgakiLingling KongRyutaro YoshidaNorihiro OkamotoMasato KinoshitaHaruka MiyazakiYuna KuEri TokunagaYuki ItoDaisuke WatanabeMakoto OoiMasakazu ShinoharaKengo SasakiYoh ZenTakenori KotaniTakashi MatozakiZibin TianYoshikatsu KanaiYuzo Kodama

Published in: Journal of gastroenterology (2023)

LAT1 affects intestinal tumor development in a cell-extrinsic manner through reduced Wnt3 expression in Paneth cells. Our findings may partly explain how nutrient availability can affect the risk of tumor development in the intestines.

Keyphrases

poor prognosis
single cell
cell therapy
stem cells
type diabetes
binding protein
cell cycle arrest
cell death
insulin resistance
signaling pathway