Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.
Junghun LeeAhreum KwonHyun Wook ChaeWoo Jung LeeTae Hyuk KimHo Seong KimPublished in: Yonsei medical journal (2019)
Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST in the hypothalamus. Further studies are needed to overcome the observed desensitization to GHS.