Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease.
Allison D TaNicholas J OllberdingRebekah KarnsYael HabermanAdina L AlazrakiDavid HerculesRobert BaldassanoJames MarkowitzMelvin B HeymanSandra KimBarbara KirschnerJason M ShapiroJoshua NoeMaria Oliva-HemkerAnthony OtleyMarian PfefferkornRichard KellermayerScott SnapperShervin RabizadehRamnik XavierMarla DubinskyJeffrey HyamsSubra KugathasanAnil G JeggaJonathan R DillmanLee A DensonPublished in: Inflammatory bowel diseases (2021)
Pediatric patients with CD with LN at diagnosis are less likely to achieve TH. The association between specific microbiota, wound healing gene programs, and LN may suggest future therapeutic targets.