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CAR T cells targeting αvβ3 integrin are effective against advanced cancer in preclinical models.
Lars Wallstabe
Andreas Mades
Silke Frenz
Hermann Einsele
Christoph Rader
Michael Hudecek
Published in:
Advances in cell and gene therapy (2018)
αvβ3-CAR T-cells have therapeutic potential in several prevalent solid tumours, including melanoma and triple-negative breast cancer.
Keyphrases
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induced apoptosis
advanced cancer
cell cycle arrest
palliative care
endoplasmic reticulum stress
stem cells
oxidative stress
drug delivery
bone marrow