The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis.
Ziru LiClifford J RosenPublished in: The Journal of clinical endocrinology and metabolism (2023)
Bone marrow adipose tissue (BMAT) makes up a significant portion of the marrow space, ranging from 50-70%, in healthy adults. It expands with aging, obesity, anorexia nervosa, and irradiation, which are conditions associated with skeletal complications or hematopoietic disorders. Therefore, BMAT has been viewed as a negative component of the bone marrow niche for decades, although the mechanisms and causative relationships have not been well-addressed. Of note, recent studies revealed that BMAT is a multifaceted tissue that can serve as an energy reservoir to fuel osteoblasts and hematopoietic cells under stressful situations, and also acts as an endocrine/paracrine organ to suppress bone formation and support hematopoiesis at steady-state conditions. In this review, we summarize the uniqueness of BMAT, the complex findings of previous studies and update our understanding of the physiological roles of BMAT in bone and hematopoietic metabolism based on a newly-established bone marrow adipocyte-specific mouse model.
Keyphrases
- bone marrow
- adipose tissue
- insulin resistance
- mesenchymal stem cells
- anorexia nervosa
- mouse model
- bone mineral density
- induced apoptosis
- type diabetes
- metabolic syndrome
- high fat diet
- case control
- weight loss
- skeletal muscle
- risk factors
- soft tissue
- bone loss
- high fat diet induced
- cell death
- single cell
- fatty acid
- postmenopausal women
- body composition
- oxidative stress
- radiation induced
- signaling pathway