Radical gastric cancer surgery results in widespread upregulation of pro-tumourigenic intraperitoneal cytokines.
Andrew J LongPaul R BurtonMichael J De VeerGeraldine J OoiCheryl P LauriePeter D NottleMatthew J WattWendy A BrownPublished in: ANZ journal of surgery (2017)
Radical surgery dramatically upregulates the expression of pro-tumourigenic cytokines in the peritoneum. There is also a marked systemic immune and inflammatory response to surgery, including downregulation of T-cell and dendritic cell populations. This offers two potential pathways that may facilitate tumour progression - local inflammation promoting peritoneal adherence and implantation, and secondary suppression of immunosurveillance due to circulating inflammatory response.
Keyphrases
- minimally invasive
- coronary artery bypass
- inflammatory response
- poor prognosis
- dendritic cells
- oxidative stress
- surgical site infection
- cell proliferation
- signaling pathway
- anti inflammatory
- metabolic syndrome
- long non coding rna
- immune response
- skeletal muscle
- toll like receptor
- atrial fibrillation
- glycemic control