Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases.
Carolyn J AdamskiTimothy G PalzkillPublished in: BMC biochemistry (2017)
Results from this study and previous studies suggest that substitutions at BLIP Tyr50 may induce changes at the interface outside its local environment and point to the complexity of predicting the impact of substitutions at a protein-protein interaction interface.