Timothy G Palzkill (Timothy Palzkill)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Topics

Urinary Tract Infection

Multidrug Resistant

Structural Basis

Top Venues

Antimicrobial agents and chemotherapy

Communications biology

Journal of medicinal chemistry

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy G Palzkill, Damian W Young, Srinivas Chamakuri
Expanding Complex Morpholines Using Systematic Chemical Diversity. Organic letters (2024)
Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy G Palzkill, Damian W Young, Srinivas Chamakuri
Expanding Complex Morpholines Using Systematic Chemical Diversity. Organic letters 26 (17) (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Allison K Judge, Banumathi Sankaran, Liya Hu, Murugesan Palaniappan, André Birgy, B V Venkataram Prasad, Timothy G Palzkill
Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Allison K Judge, Banumathi Sankaran, Liya Hu, Murugesan Palaniappan, André Birgy, B V Venkataram Prasad, Timothy G Palzkill
Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Allison K Judge, Banumathi Sankaran, Liya Hu, Murugesan Palaniappan, André Birgy, B V Venkataram Prasad, Timothy G Palzkill
Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy G Palzkill, Damian W Young, Srinivas Chamakuri
Expanding Complex Morpholines Using Systematic Chemical Diversity. Organic letters (2024)
Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy G Palzkill, Damian W Young, Srinivas Chamakuri
Expanding Complex Morpholines Using Systematic Chemical Diversity. Organic letters (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Andre Birgy, Christina Nnabuife, Timothy G Palzkill
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrobial agents and chemotherapy 68 (3) (2024)
Allison K Judge, Banumathi Sankaran, Liya Hu, Murugesan Palaniappan, André Birgy, B V Venkataram Prasad, Timothy G Palzkill
Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Allison K Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B V Venkataram Prasad, Timothy G Palzkill
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase. Communications biology 6 (1) (2023)
Lynn Su, Wanzhi Huang, Frederick H Neill, Mary K Estes, Robert L Atmar, Timothy G Palzkill
Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response. NPJ vaccines 8 (1) (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Allison K Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B V Venkataram Prasad, Timothy G Palzkill
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase. Communications biology 6 (1) (2023)
Chao Yin, Zilin Song, Hao Tian, Timothy G Palzkill, Peng Tao
Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning. Physical chemistry chemical physics : PCCP 25 (2) (2023)
Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B V Venkataram Prasad, Martin M Matzuk, Timothy G Palzkill
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. Journal of medicinal chemistry 67 (1) (2023)
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C Faver, Pranavanand Nyshadham, Kiran L Sharma, Banumathi Sankaran, Allison K Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S Harris, Martin M Matzuk, Timothy G Palzkill, Damian W Young
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Communications chemistry 6 (1) (2023)
Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B V Venkataram Prasad, Martin M Matzuk, Timothy G Palzkill
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. Journal of medicinal chemistry (2023)
Chao Yin, Zilin Song, Hao Tian, Timothy G Palzkill, Peng Tao
Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning. Physical chemistry chemical physics : PCCP 25 (2) (2023)
Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B V Venkataram Prasad, Martin M Matzuk, Timothy G Palzkill
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. Journal of medicinal chemistry 67 (1) (2023)
Allison K Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B V Venkataram Prasad, Timothy G Palzkill
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase. Communications biology 6 (1) (2023)
Allison K Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B V Venkataram Prasad, Timothy G Palzkill
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase. Communications biology 6 (1) (2023)
Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B V Venkataram Prasad, Martin M Matzuk, Timothy G Palzkill
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. Journal of medicinal chemistry 67 (1) (2023)
Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B V Venkataram Prasad, Martin M Matzuk, Timothy G Palzkill
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. Journal of medicinal chemistry 67 (1) (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Allison K Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B V Venkataram Prasad, Timothy G Palzkill
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase. Communications biology 6 (1) (2023)
Chao Yin, Zilin Song, Hao Tian, Timothy G Palzkill, Peng Tao
Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning. Physical chemistry chemical physics : PCCP (2022)
Shuo Lu, Liya Hu, Hanfeng Lin, Allison K Judge, Paola Rivera, Murugesan Palaniappan, Banumathi Sankaran, Jin Wang, B V Venkataram Prasad, Timothy G Palzkill
An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes. Nature communications 13 (1) (2022)
Zhizeng Sun, Lynn Su, Nicole Cotroneo, Ian Critchley, Michael Pucci, Akash Jain, Timothy G Palzkill
Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections. Antimicrobial agents and chemotherapy 66 (5) (2022)
Patricia A Bradford, Robert A Bonomo, Karen Bush, Alessandra Carattoli, Michael Feldgarden, Daniel H Haft, Yoshikazu Ishii, George A Jacoby, William Klimke, Timothy G Palzkill, Laurent Poirel, Gian Maria Rossolini, Pranita D Tamma, César A Arias
Consensus on β-Lactamase Nomenclature. Antimicrobial agents and chemotherapy 66 (4) (2022)
Doris Mia Taylor, Justin Anglin, Liya Hu, Lingfei Wang, Banumathi Sankaran, Jin Wang, Martin M Matzuk, B V Venkataram Prasad, Timothy G Palzkill
Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. ACS infectious diseases 7 (12) (2021)
Vlatko Stojanoski, Liya Hu, Banumathi Sankaran, Feng Wang, Peng Tao, B V Venkataram Prasad, Timothy G Palzkill
Mechanistic Basis of OXA-48-like β-Lactamases' Hydrolysis of Carbapenems. ACS infectious diseases 7 (2) (2021)
David M Boragine, Wanzhi Huang, Lynn H Su, Timothy G Palzkill
Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. Chembiochem : a European journal of chemical biology (2021)
Zhizeng Sun, Timothy G Palzkill
Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1. mBio (2021)
Sandra Rincon, Lina P Carvajal, Sara I Gomez-Villegas, Aura M Echeverri, Rafael Rios, An Dinh, Claudia Pedroza, Karen M Ordoñez, Esteban Nannini, Zhizeng Sun, Vance G Fowler, Barbara E Murray, William R Miller, Timothy G Palzkill, Lorena Diaz, Cesar A Arias, Jinnethe Reyes
A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus. Journal of clinical microbiology 59 (4) (2021)
James M Musser, Stephen B Beres, Luchang Zhu, Randall J Olsen, Jaana Vuopio, Hanne-Leena Hyyryläinen, Kirsi Gröndahl-Yli-Hannuksela, Karl G Kristinsson, Jessica Darenberg, Birgitta Henriques-Normark, Steen Hoffmann, Dominque A Caugant, Andrew J Smith, Diane S J Lindsay, David M Boragine, Timothy G Palzkill
Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread. Journal of clinical microbiology 58 (4) (2020)
Shuo Lu, Victoria Soeung, Hoang A T Nguyen, Scott Wesley Long, James M Musser, Timothy G Palzkill
Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates. mSphere 5 (1) (2020)
Andrew R Mack, Melissa D Barnes, Magdalena A Taracila, Andrea M Hujer, Kristine M Hujer, Gabriel Cabot, Michael Feldgarden, Daniel H Haft, William Klimke, Focco van den Akker, Alejandro J Vila, Andrea Smania, Shozeb Haider, Krisztina M Papp-Wallace, Patricia A Bradford, Gian Maria Rossolini, Jean-Denis Docquier, Jean-Marie Frère, Moreno Galleni, Nancy D Hanson, Antonio Oliver, Patrick Plésiat, Laurent Poirel, Patrice Nordmann, Timothy G Palzkill, George A Jacoby, Karen Bush, Robert A Bonomo
A Standard Numbering Scheme for Class C β-Lactamases. Antimicrobial agents and chemotherapy 64 (3) (2020)
Doris Mia Taylor, Justin Anglin, Suhyeorn Park, Melek N Ucisik, John C Faver, Nicholas Simmons, Zhuang Jin, Murugesan Palaniappan, Pranavanand Nyshadham, Feng Li, James Campbell, Liya Hu, Banumathi Sankaran, B V Venkataram Prasad, Hongbing Huang, Martin M Matzuk, Timothy G Palzkill
Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS infectious diseases 6 (5) (2020)
Wanzhi Huang, Victoria Soeung, David M Boragine, Timothy G Palzkill
Mapping Protein-Protein Interaction Interface Peptides with Jun-Fos Assisted Phage Display and Deep Sequencing. ACS synthetic biology 9 (7) (2020)
Wanzhi Huang, Victoria Soeung, David M Boragine, Liya Hu, B V Venkataram Prasad, Mary K Estes, Robert L Atmar, Timothy G Palzkill
High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. Journal of virology 95 (1) (2020)
Jianwei Chen, Xiqian Jiang, Chengwei Zhang, Kevin R MacKenzie, Fabio Stossi, Timothy G Palzkill, Meng C Wang, Jin Wang
Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS sensors 2 (9) (2017)
Meha P Patel, Liya Hu, Vlatko Stojanoski, Banumathi Sankaran, B V Venkataram Prasad, Timothy G Palzkill
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry 56 (27) (2017)
Carolyn J Adamski, Timothy G Palzkill
BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases. Biochemistry 56 (8) (2017)
Carolyn J Adamski, Timothy G Palzkill
Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases. BMC biochemistry 18 (1) (2017)
Vlatko Stojanoski, Banumathi Sankaran, B V Venkataram Prasad, Laurent Poirel, Patrice Nordmann, Timothy G Palzkill
Structure of the catalytic domain of the colistin resistance enzyme MCR-1. BMC biology 14 (1) (2016)