Lower versus higher blood pressure targets in comatose patients resuscitated from out-of-hospital cardiac arrest-Protocol for a secondary Bayesian analysis of the box trial.
Johannes GrandSebastian WibergJesper KjaergaardChristian HassagerHenrik SchmidtJacob E MøllerSimon MølstrømAnders GranholmPublished in: Acta anaesthesiologica Scandinavica (2024)
This secondary analysis of the BOX trial aim to complement the primary frequentist analysis by quantifying the probabilities of beneficial or harmful effects of different blood pressure targets. This approach seeks to provide clearer insights for researchers and clinicians into the effectiveness of these blood pressure management strategies in acute medical conditions, particularly focusing on mortality, neurological outcomes, and neuron-specific enolase.
Keyphrases
- blood pressure
- cardiac arrest
- hypertensive patients
- randomized controlled trial
- end stage renal disease
- heart rate
- study protocol
- phase iii
- clinical trial
- transcription factor
- ejection fraction
- newly diagnosed
- chronic kidney disease
- phase ii
- systematic review
- liver failure
- binding protein
- type diabetes
- palliative care
- cardiovascular events
- cardiovascular disease
- risk factors
- adipose tissue
- respiratory failure
- hepatitis b virus
- blood glucose
- coronary artery disease
- patient reported
- intensive care unit
- aortic dissection
- drug induced
- blood brain barrier
- mechanical ventilation
- data analysis
- acute respiratory distress syndrome