Merkel cell carcinoma mimicking acute leukemia.

Jonathan KeowKeith F KwanBen D HedleyCyrus C HsiaAnargyros XenocostasBenjamin Chin-Yee

Published in: International journal of laboratory hematology (2024)

Bone marrow aspirate showed diffuse infiltration by a population of monomorphic cells with scant cytoplasm, markedly increased nuclear-to-cytoplasmic ratio, and numerous indistinct nucleoli. Bone marrow biopsy confirmed extensive marrow infiltration by a malignant neoplasm with strong and diffuse expression of synaptophysin by immunohistochemistry, consistent with metastases from Merkel Cell carcinoma.

Keyphrases

bone marrow
low grade
mesenchymal stem cells
induced apoptosis
poor prognosis
cell cycle arrest
high grade
ultrasound guided
cell death
oxidative stress
signaling pathway
fine needle aspiration
long non coding rna