Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes.

Anshita GoelDouglas G WardBoris NoyvertMinghao YuNaheema S GordonBen AbbottsJohn K ColbourneStephen KissaneNicholas D JamesMaurice P ZeegersKar Keung ChengJean-Baptiste CazierCelina M WhalleyAndrew D BeggsClaire PallesRoland ArnoldRichard T Bryan

Published in: Genome medicine (2022)

Multi-omic data may facilitate better prognostication and selection of therapeutic interventions in patients with G3pT1 NMIBC. These findings demonstrate the potential for improving the management of high-risk NMIBC patients and warrant further prospective validation.

Keyphrases

muscle invasive bladder cancer
end stage renal disease
ejection fraction
single cell
newly diagnosed
poor prognosis
copy number
physical activity
gene expression
peritoneal dialysis
prognostic factors
genome wide
rna seq
dna methylation
long non coding rna
big data
patient reported outcomes
artificial intelligence