Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery.

Chris KatoKoji UedaSatoru MorimotoShinichi TakahashiShiho NakamuraFumiko OzawaDaisuke ItoYugaku DatéKensuke OkadaNaoki KobayashiJin NakaharaHideyuki Okano

Published in: Inflammation and regeneration (2024)

Despite the limited sample size, this study pioneers in reporting time-series proteomic alterations in serum and CSF EVs from SALS patients, offering comprehensive insights into SALS pathogenesis, ROPI-induced changes, and potential prognostic and diagnostic biomarkers.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
small molecule
prognostic factors
emergency department
high throughput
adverse drug
risk assessment
endothelial cells
patient reported outcomes
climate change