Serum-Induced Expression of Brain Natriuretic Peptide Contributes to Its Increase in Patients with HFpEF.
Ryuji OkamotoRyotaro HashizumeNoboru SuzukiRie ItoTomoko TokuharaHiroshi FujiwaraYe ZheHiromasa ItoTakaya AbeKaoru DohiPublished in: International journal of molecular sciences (2022)
Brain natriuretic peptide (BNP) levels are increased in both patients with heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF), but the reasons for this remain unclear. Our purpose was to examine whether serum-induced BNP (iBNP) expression partly contributes to increased BNP in patients with HFpEF. BNP reporter cardiomyocytes from pBNP-luc-KI mice were stimulated with serum from patients with HFpEF or HFrEF ( n = 114 and n = 82, respectively). Luciferase activity was examined as iBNP and the iBNP-to-BNP ratio was evaluated. Patient characteristics and clinical parameters were compared, and multivariate regression analysis was performed to determine independent predictors of the iBNP-to-BNP ratio. Female sex and frequencies of atrial fibrillation, hypertension and the use of a calcium channel blocker (CCB) were higher in HFpEF. The iBNP-to-BNP ratio was significantly higher in HFpEF (26.9) than in HFrEF (16.1, p < 0.001). Multivariate regression analysis identified the existence of HFpEF as an independent predictor of the iBNP-to-BNP ratio after adjusting for all other measurements (β = 0.154, p = 0.032). Age, hemoglobin, CCB usage and deceleration time were also independent predictors (β = 0.167, p = 0.025; β = 0.203, p = 0.006; β = 0.138, p = 0.049; and β = 0.143, p = 0.049, respectively). These results indicate that the elevated BNP in patients with HFpEF is partly due to iBNP from the heart.
Keyphrases
- atrial fibrillation
- poor prognosis
- high glucose
- blood pressure
- heart failure
- white matter
- squamous cell carcinoma
- diabetic rats
- metabolic syndrome
- case report
- crispr cas
- coronary artery disease
- multiple sclerosis
- mitral valve
- blood brain barrier
- long non coding rna
- venous thromboembolism
- insulin resistance
- lymph node
- drug induced
- left ventricular
- neoadjuvant chemotherapy
- red blood cell
- locally advanced