Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose-ranging study.

Steven ThorntonGuillermo ValenzuelaCharlotte BaidooMichael J FosslerTimothy H MontagueLinda ClaytonMarcy PowellJerry SnidowBrendt StierDavid Soergel

Published in: British journal of clinical pharmacology (2017)

Intravenous retosiban has a favourable safety and tolerability profile and might prolong pregnancies in women with PTL. The study provides the rationale and dosing strategy for further evaluation of the efficacy of retosiban in the treatment of PTL.

Keyphrases

phase ii
clinical trial
open label
preterm birth
randomized controlled trial
gestational age
high dose
study protocol
combination therapy
low birth weight
placebo controlled
double blind
smoking cessation
phase iii
pregnancy outcomes