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Effects of 6 weeks of treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes: A randomized, placebo-controlled, exploratory study.

Jonas OldgrenSanna LaurilaAxel ÅkerblomAino Latva-RaskuEleni RebelosHenrik IsacksonMaria SaarenhoviOlof ErikssonKerstin HeurlingEdvin JohanssonUlrica WilderängCecilia KarlssonRussell EsterlineEleuterio FerranniniJan OscarssonPirjo Nuutila
Published in: Diabetes, obesity & metabolism (2021)
This exploratory study indicates reduced heart work but limited effects on myocardial function, efficiency and cardiac fatty acid uptake, while hepatic fatty acid uptake increased, after 6 weeks of treatment with dapagliflozin.
Keyphrases
  • fatty acid
  • left ventricular
  • heart failure
  • squamous cell carcinoma
  • placebo controlled
  • clinical trial
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  • phase ii