Effects of 6 weeks of treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes: A randomized, placebo-controlled, exploratory study.
Jonas OldgrenSanna LaurilaAxel ÅkerblomAino Latva-RaskuEleni RebelosHenrik IsacksonMaria SaarenhoviOlof ErikssonKerstin HeurlingEdvin JohanssonUlrica WilderängCecilia KarlssonRussell EsterlineEleuterio FerranniniJan OscarssonPirjo NuutilaPublished in: Diabetes, obesity & metabolism (2021)
This exploratory study indicates reduced heart work but limited effects on myocardial function, efficiency and cardiac fatty acid uptake, while hepatic fatty acid uptake increased, after 6 weeks of treatment with dapagliflozin.