Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies.
Maura MalpettiSebastian N RoemerStefanie HarrisMattes GrossJohannes GnörichAndrew StephensAnna DewenterAnna StewardDavina BielAmir DehsarviFabian WagnerAndre MüllerNorman KoglinEndy WeidingerCarla PalleisSabrina KatzdoblerRainer RupprechtRobert PerneczkyBoris-Stephan RauchmannJohannes LevinGünter U HöglingerMatthias BrendelNicolai FranzmeierPublished in: Movement disorders : official journal of the Movement Disorder Society (2024)
Our findings indicate that the spatial expansion of microglial activation parallels tau distribution across brain regions that are functionally connected to each other, suggesting that tau and inflammation are closely interrelated in patients with 4R tauopathies. The combination of in vivo tau and inflammatory biomarkers could therefore support the development of immunomodulatory strategies for disease-modifying treatments in these conditions. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- positron emission tomography
- computed tomography
- cerebrospinal fluid
- oxidative stress
- lipopolysaccharide induced
- lps induced
- inflammatory response
- pet imaging
- pet ct
- traumatic brain injury
- cerebral ischemia
- white matter
- resting state
- systematic review
- neuropathic pain
- spinal cord injury
- randomized controlled trial
- multiple sclerosis
- spinal cord
- blood brain barrier