Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain.

Naoko H TomiokaYoshifuru TamuraTappei TakadaShigeru ShibataHiroshi SuzukiShunya UchidaMakoto Hosoyamada

Published in: Fluids and barriers of the CNS (2016)

We propose that given their specific expression patterns in ependymal, choroid plexus epithelial, and brain capillary endothelial cells in this study, UA may be transported by these UA transporters in the murine brain. This may provide a novel strategy for targeted neuroprotection.

Keyphrases

endothelial cells
white matter
resting state
cerebral ischemia
poor prognosis
functional connectivity
brain injury
multiple sclerosis
drug delivery
cancer therapy
blood brain barrier
binding protein
ultrasound guided