Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells.

Saime Güzel Abdullah Yalcin Yunus Gürpinar Sabire Güler

Published in: Turkish journal of medical sciences (2023)

These findings suggest that Pfkfb2 and Pfkfb3 may impact the differentiation of mESCs into IPCs and the regulation of the insulin response to glucose levels. This study also lays a foundation for researchers to further probe the roles of Pfkfb isoenzymes on the differentiation of mESCs into IPCs and may open new avenues for regenerative medicine.

Keyphrases

embryonic stem cells
type diabetes
induced apoptosis
poor prognosis
minimally invasive
blood pressure
quantum dots
oxidative stress
living cells
endoplasmic reticulum stress
insulin resistance
cell death