TNF-Blockade for Primary Stroke Prevention in Adenosine Deaminase 2 Deficiency: A Case Series.

Ariane SoldatosCamilo ToroPatrycja HoffmannTina RomeoNatalie DeuitchAlessandra BrofferioIvona AksentijevichDaniel L KastnerAmanda K Ombrello

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

This family illustrates the importance of testing for DADA2 in young patients with cryptogenic stroke, given the hemorrhagic risks with antiplatelet drugs in these patients and effectiveness of TNF blockade as secondary stroke prevention. In addition, this family highlights the importance of screening all siblings of affected patients because they may be presymptomatic, and we advocate starting TNF blockade for primary stroke prevention in those who are found to be genetically or biochemically affected.

Keyphrases

atrial fibrillation
end stage renal disease
rheumatoid arthritis
ejection fraction
newly diagnosed
chronic kidney disease
randomized controlled trial
prognostic factors
systematic review
patient reported outcomes
risk assessment
climate change
cerebral ischemia
middle aged
patient reported
protein kinase