Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors.
Gloria Maria da SilvaDaniel Henrique Berto de SouzaKaroline B WaitmanMatteo Celano EbramMelissa R FesselIuliu Cezar ZainescuFernanda Calheta Vieira PortaroMontse HerasSonia A de AndradePublished in: The journal of venomous animals and toxins including tropical diseases (2021)
Our study identified two small peptides able to inhibit bothropic serine proteases, but not human ones, can be used as tools to enhance knowledge of the venom composition and function. Moreover, one promising peptide (pepC) was identified that can be explored in the search for improving Bothrops spp. envenomation treatment.