Prevalence and risk factors of osteonecrosis of the femoral head in patients with ANCA-associated vasculitis: a multicentre cohort study.

Norihiro Mimura Taro Iwamoto Shunsuke Furuta Kei Ikeda Yoshihisa Kobayashi Takayuki Nakamura Aiko Saku Shin-Ichiro Kagami Ayako Matsuki Kentaro Takahashi Takeshi Umibe Daiki Nakagomi Yoshie Sanayama Toyohiko Sugimoto Masashi Fukuta Masaki Hiraguri Hirotoshi Kawashima Koichi Hirose Hiroaki Takatori Kenichi Suehiro Shigekazu Takahashi Tomohiro Tamachi Manami Kato Fumiyoshi Takizawa Yuuya Kawarai Shigeo Hagiwara Junichi Nakamura Seiji Ohtori Hiroshi Nakajima

Published in: RMD open (2023)

Eighteen per cent of AAV patients developed ONFH, and two-thirds of the ONFH joints were already in collapse stages or at risk of future collapse. Prednisolone dose of ≥20 mg/day on day 90 of RIT was an independent risk factor for ONFH. A rapid reduction of glucocorticoids in RIT and early detection of precollapse ONFH by MRI may decrease and intervene ONFH development in AAV patients.

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