Mechanisms of insulin resistance in type 1 diabetes mellitus: A case of glucolipotoxicity in skeletal muscle.
Mitchell J SammutMichelle S DotzertC W James MellingPublished in: Journal of cellular physiology (2024)
Insulin resistance (IR), a hallmark of type 2 diabetes mellitus, develops in a significant number of patients with type 1 diabetes mellitus (T1DM) despite the use of insulin therapy to control glycemia. However, little is currently understood regarding the underlying mechanisms of IR in T1DM, especially within the context of chronic insulin treatment. Recent evidence suggests an important influence of glucolipotoxicity in skeletal muscle on insulin sensitivity in T1DM. Thus, this review summarizes our current knowledge regarding impairments in skeletal muscle lipid, glucose, and oxidative metabolism in the development of IR in insulin-treated T1DM.
Keyphrases
- insulin resistance
- skeletal muscle
- glycemic control
- type diabetes
- blood glucose
- high fat diet
- polycystic ovary syndrome
- adipose tissue
- end stage renal disease
- high fat diet induced
- metabolic syndrome
- newly diagnosed
- chronic kidney disease
- ejection fraction
- healthcare
- peritoneal dialysis
- prognostic factors
- fatty acid
- stem cells
- blood pressure
- weight loss