Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs.
Mehran AmrovaniMohammadjavad MohammadtaghizadehMahsa Karimzadeh AghaaliSomayeh ZamanifardArash AlqasiZari Tahannejad AsadiPublished in: Cardiovascular toxicology (2021)
One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200-1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.
Keyphrases
- long non coding rna
- poor prognosis
- cell cycle arrest
- locally advanced
- cell proliferation
- induced apoptosis
- drug induced
- stem cells
- cell death
- endoplasmic reticulum stress
- oxidative stress
- pi k akt
- chemotherapy induced
- high glucose
- case report
- squamous cell carcinoma
- network analysis
- rectal cancer
- risk assessment
- genome wide identification
- human health
- climate change
- long noncoding rna
- genome wide analysis
- wound healing