Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.
Urszula RykaczewskaQuanyi ZhaoPeter Saliba-GustafssonMariette LengquistMalin KronqvistOtto BergmanZhiqiang HuangKent LundKatarina WadenZara Pons VilaKenneth CaidahlJosefin SkogsbergVladana VukojevicJan H N LindemanJoy RoyGöran K HanssonEckardt TreuterNicholas J LeeperPer ErikssonEwa EhrenborgAnton RazuvaevUlf HedinLjubica MaticPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.
Keyphrases
- smooth muscle
- single cell
- coronary artery disease
- cardiovascular disease
- climate change
- magnetic resonance imaging
- cell therapy
- adipose tissue
- transcription factor
- genome wide
- copy number
- fatty acid
- gene expression
- genome wide identification
- stem cells
- computed tomography
- mesenchymal stem cells
- contrast enhanced ultrasound
- bone marrow