Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia.

Jung-Lin Wu Hsin-Yi WuShang-Ju WuHo-Yang TsaiShao-Hsing WengKuen-Tyng LinLiang-In LinChi-Yuan YaoMargarita Zamanova Yi-Yuan Lee Takashi AngataHwei-Fang TienYi-Ju Chen Kuo-I Lin

Published in: Molecular cancer research : MCR (2022)

This phosphoproteomic analysis and functional validation illuminated the phosphorylation of KAP1 at S473 as an important downstream BCR signaling event and a potential indicator for the success of ibrutinib treatment in CLL.

Keyphrases

chronic lymphocytic leukemia
protein kinase
acute lymphoblastic leukemia
tyrosine kinase
combination therapy
risk assessment
chronic myeloid leukemia