Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records.
QiPing FengWei-Qi WeiCecilia P ChungRebecca T LevinsonAlexandra C SundermannJonathan D MosleyLisa BastaracheJane F FergusonNancy J CoxDan M RodenJoshua C DennyMacRae F LintonDigna R Velez EdwardsC Michael SteinPublished in: PLoS medicine (2018)
Very low LDL-C concentrations occurring in the absence of statin treatment were significantly associated with T2DM risk in a large EHR population; this increased risk was present in both sexes and all BMI categories, and in individuals of European ancestry but not of African ancestry. Longitudinal cohort studies to assess the relationship between very low LDL-C levels not associated with lipid-lowering therapy and risk of developing T2DM will be important.