Analysis of Methylome, Transcriptome, and Lipid Metabolites to Understand the Molecular Abnormalities in Polycystic Ovary Syndrome.

Fei ZhangYicen DingBohan ZhangMengju HeZhijiang WangChunbo LuYani Kang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)

Using integration of methylome and lipid metabolites profiling we identified 8 potential epigenetic markers and 15 potential lipid metabolite markers for PCOS. Our results suggest that aberrant DNA methylation and lipid metabolite disorders may provide novel insights into the diagnosis and etiology of PCOS.

Keyphrases

polycystic ovary syndrome
dna methylation
insulin resistance
gene expression
fatty acid
ms ms
type diabetes
human health
risk assessment