The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1.

Sang Hoon LeeJu Hye ShinMi Hwa ShinYoung Sam KimKyung Soo ChungJoo Han SongSong Yee KimEun Young KimJi Ye JungYoung Ae KangJoon ChangMoo Suk Park

Published in: Tuberculosis and respiratory diseases (2018)

RA had inhibitory effects on the phosphorylation of Smad induced by TGF-β1 in vitro, and RA also decreased the expression of TGF-β1 at 1 and 3 weeks in vivo. Furthermore, pre-treatment with a MAPK inhibitor showed a preventative effect on TGF-β1/Smad phosphorylation in epithelial cells. As a result, a combination of RA and MAPK inhibitors may suppress the TGF-β1-induced lung injury and fibrosis.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
rheumatoid arthritis
oxidative stress
pi k akt
protein kinase
disease activity
poor prognosis
ankylosing spondylitis
diabetic rats
interstitial lung disease
drug induced