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Acquired vibratory angioedema with a severe impact on work performance.

Maria-Elena Gatica-OrtegaI Sánchez-MatasL Sánchez-MuñozM A Pastor-Nieto
Published in: Occupational medicine (Oxford, England) (2022)
Vibratory urticaria/angioedema is an inducible type of urticaria that may be elicited by vibratory stimuli from work tool and instruments. A 39-year-old male construction worker was diagnosed with acquired vibratory angioedema associated with chronic spontaneous urticaria involving a severe work performance impairment. Response to omalizumab was immediate and complete. We evaluated the Urticarial Activity Score; the response to the vibratory angioedema provocation vortex test; and evolution of analytical parameters (e.g. high-affinity IgE receptor expression on peripheral blood basophils, C-reactive protein, D-dimer and IgE levels). Vibratory angioedema may be misdiagnosed as delayed pressure urticaria if the appropriate specific provocation tests are not performed. According to our knowledge, this is the first time a pneumatic hammer is described as a trigger; the first case responding to omalizumab; and the second published case associated with spontaneous chronic urticaria.
Keyphrases
  • angiotensin converting enzyme
  • peripheral blood
  • angiotensin ii
  • early onset
  • healthcare
  • drug induced
  • randomized controlled trial
  • systematic review
  • liquid chromatography