Neutrophils cultured ex vivo from CD34 + stem cells are immature and genetically tractable.

Claire A NavehKiran RobertsPrzemysław ZakrzewskiChristopher M RiceFernando M Ponce-GarciaKathryn FlemingMegan ThompsonNawamin PanyapieanHuan JiangStephanie DiezmannPedro L MouraAshley M ToyeBorko Amulic

Published in: Journal of translational medicine (2024)

Ex vivo cultured neutrophils are genetically tractable via genome editing of precursors and provide a powerful model system for investigating the properties and behaviour of immature neutrophils.

Keyphrases

genome editing
crispr cas
stem cells
endothelial cells
cell therapy