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Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease.

Giuseppe PompilioAndrew NicolaidesStavros K KakkosDavide Integlia
Published in: Phlebology (2021)
Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD. VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies. The relative effectiveness of sulodexide and VADs needs to be evaluated by an RCT in order to better inform clinical practice.
Keyphrases
  • systematic review
  • clinical practice
  • randomized controlled trial
  • case report
  • meta analyses
  • sleep quality