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iRhom2 and TNF: Partners or enemies?

Marina BadenesColin Adrain
Published in: Science signaling (2019)
iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
Keyphrases
  • rheumatoid arthritis
  • liver fibrosis
  • cell surface
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • human immunodeficiency virus