Single-cell identification by microfluidic-based in situ extracting and online mass spectrometric analysis of phospholipids expression.

Qiushi Huang Sifeng MaoMashooq KhanWeiwei Li Qiang Zhang Jin-Ming Lin

Published in: Chemical science (2019)

This work describes a microfluidic system for in situ extraction of a single-cell and its phosphatidylcholine analysis through mass spectrometry. This approach uncovered cellular heterogeneity among seemingly identical cells and provided a new platform for identification and classification of cells.

Keyphrases

single cell
high throughput
rna seq
induced apoptosis
mass spectrometry
cell cycle arrest
machine learning
circulating tumor cells
poor prognosis
signaling pathway
deep learning
oxidative stress
high resolution
social media
health information