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Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.

Matthew A SpinelliBrentton LoweryJennifer A ShufordJon SpindlerMary F KearneyJenny R McFarlaneCheryl McDonaldHideaki OkochiNhi PhungKaren KunczeKathryn JeeDeeJay JohannessenPeter L AndersonDawn K SmithPatricia DefechereuxRobert M GrantMonica Gandhi
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.
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