Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.
Matthew A SpinelliBrentton LoweryJennifer A ShufordJon SpindlerMary F KearneyJenny R McFarlaneCheryl McDonaldHideaki OkochiNhi PhungKaren KunczeKathryn JeeDeeJay JohannessenPeter L AndersonDawn K SmithPatricia DefechereuxRobert M GrantMonica GandhiPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.
Keyphrases
- human immunodeficiency virus
- public health
- men who have sex with men
- hepatitis c virus
- antiretroviral therapy
- single cell
- hiv positive
- hiv infected
- genome wide
- adverse drug
- hiv aids
- atomic force microscopy
- drug induced
- metabolic syndrome
- emergency department
- dna methylation
- high resolution
- global health
- gene expression
- electronic health record
- glycemic control