Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells.

Jing WangShuqin LiuXinxiu MengXuan ZhaoTianhui WangZhiyong Lei Helge Immo Lehmann Guoping Li Pilar Alcaide Yihua Bei Junjie Xiao

Published in: Circulation research (2024)

Our results demonstrate that exercise training protects against doxorubicin-induced cardiotoxicity by upregulating Fc gamma receptor IIB expression in B cells, which plays an important anti-inflammatory role and participates in the protective effect of exercise against doxorubicin-induced cardiotoxicity.

Keyphrases

high glucose
diabetic rats
drug delivery
drug induced
anti inflammatory
high intensity
cancer therapy
physical activity
poor prognosis
skeletal muscle
endothelial cells
oxidative stress
resistance training
binding protein