An Fe-based single-atom nanozyme with multi-enzyme activity for parallel catalytic therapy via a cascade reaction.
Rui NiuYang LiuYinghui WangHong-Jie ZhangPublished in: Chemical communications (Cambridge, England) (2022)
Here, we report Fe-based single-atom nanozymes, which were fabricated by embedding Fe atoms into N-doped hollow carbon spheres. The nanozymes (FeSA-HNCSB) exhibit the efficient catalytic generation of ROS in the tumor microenvironment (TME). They possess multiple enzyme-mimicking activities, including catalase-like, oxidase-like, and peroxidase-like activities. Furthermore, the FeSA-HNCSB nanozymes also exhibit good photothermal conversion efficiency in the near-infrared (NIR) region, making them potential candidates for photothermal therapy (PTT) and photothermal-enhanced catalytic therapy. This work provides a new paradigm for integrating parallel catalytic therapy and PTT to improve the effectiveness of tumor treatment.
Keyphrases
- photodynamic therapy
- metal organic framework
- randomized controlled trial
- cancer therapy
- drug delivery
- drug release
- crystal structure
- cell death
- dna damage
- quantum dots
- bone marrow
- fluorescence imaging
- oxidative stress
- high resolution
- mass spectrometry
- nitric oxide
- risk assessment
- climate change
- replacement therapy
- human health