Reduced monocyte adhesion to aortae of diabetic plasminogen activator inhibitor-1 knockout mice.
Ruozhi ZhaoKhuong LeMohammed H MoghadasianGarry X ShenPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)
The findings suggest that PAI-1 is required for diabetes-induced monocyte adhesion via interactions with uPA/uPAR, and it also regulates TLR4 and TNFα expression in vascular EC. Inhibition of PAI-1 potentially reduces vascular inflammation under diabetic condition.
Keyphrases