ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.
Xiaoyun WangDuo ZhangAndrew HighamSophie WolosiankaXiaoyan GaiLu ZhouHans PetersenVictor Pinto-PlataMiguel DivoEdwin K SilvermanBartolome CelliDave SinghYongchang SunCaroline A OwenPublished in: Respiratory research (2020)
These results link increased ADAM15 expression especially in lung leukocytes and bronchial epithelial cells to the pathogenesis of COPD.