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ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.

Xiaoyun WangDuo ZhangAndrew HighamSophie WolosiankaXiaoyan GaiLu ZhouHans PetersenVictor Pinto-PlataMiguel DivoEdwin K SilvermanBartolome CelliDave SinghYongchang SunCaroline A Owen
Published in: Respiratory research (2020)
These results link increased ADAM15 expression especially in lung leukocytes and bronchial epithelial cells to the pathogenesis of COPD.
Keyphrases
  • poor prognosis
  • chronic obstructive pulmonary disease
  • lung function
  • binding protein
  • peripheral blood
  • cystic fibrosis
  • air pollution