ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.

Xiaoyun WangDuo ZhangAndrew HighamSophie WolosiankaXiaoyan GaiLu ZhouHans PetersenVictor Pinto-PlataMiguel DivoEdwin K SilvermanBartolome CelliDave SinghYongchang SunCaroline A Owen

Published in: Respiratory research (2020)

These results link increased ADAM15 expression especially in lung leukocytes and bronchial epithelial cells to the pathogenesis of COPD.

Keyphrases

poor prognosis
chronic obstructive pulmonary disease
lung function
binding protein
peripheral blood
cystic fibrosis
air pollution