The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology.

Patrizia StracciaChiara BrunelliEsther Diana RossiPaola LanzaMaurizio MartiniTeresa MusarraCelestino Pio LombardiAlfredo PontecorviGuido Fadda

Published in: Cytopathology : official journal of the British Society for Clinical Cytology (2019)

The use of antibody VE-1 is a reliable method and a negative result of VE1 immunostaining might help to save time and money, restricting the molecular test to antibody-positive cases only. The identification of the aggressive variants of papillary carcinoma might be enabled by the expression of the antibody in neoplastic cells with tall cell features.

Keyphrases

poor prognosis
copy number
induced apoptosis
lymph node
cell cycle arrest
lymph node metastasis
squamous cell carcinoma
single cell
binding protein
cell death
ionic liquid
oxidative stress
long non coding rna
cell therapy
mesenchymal stem cells
cell proliferation
dna methylation
pi k akt
wild type