The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology.
Patrizia StracciaChiara BrunelliEsther Diana RossiPaola LanzaMaurizio MartiniTeresa MusarraCelestino Pio LombardiAlfredo PontecorviGuido FaddaPublished in: Cytopathology : official journal of the British Society for Clinical Cytology (2019)
The use of antibody VE-1 is a reliable method and a negative result of VE1 immunostaining might help to save time and money, restricting the molecular test to antibody-positive cases only. The identification of the aggressive variants of papillary carcinoma might be enabled by the expression of the antibody in neoplastic cells with tall cell features.