Equipoise Lost? Trial Conduct Challenges in an Era of Breakthrough Therapies.

Jaleh FallahFlora MulkeyMallorie H FieroHaley GittlemanChi SongJeevan PuthiamadathilAnup AmatyaSundeep AgrawalPaz VellankiDaniel L SuzmanHarpreet SinghLaleh Amiri-KordestaniPallavi Mishra-KalyaniRichard PazdurPaul G Kluetz

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

FDA Oncology Center's @Falleh_Fallah and colleagues discuss loss of equipoise and other trial conduct challenges in an era of breakthrough therapies - via @JCO_ASCO.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
palliative care
randomized controlled trial
open label
double blind