Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice.

Huayi SuoHaoxiang WangYue YangYuting GouZhiying WangDingyi YangChong Li

Published in: Drug design, development and therapy (2021)

Silymarin, which exhibits antioxidative and anti-inflammatory effects, can alleviate the liver, lung, and kidney damage induced by D-galactose/lipopolysaccharide. High-dose (150 mg/kg·bw) silymarin can more effectively inhibit organ damage, compared with low-dose silymarin (75 mg/kg·bw) in Kunming mice.

Keyphrases

lps induced
high dose
low dose
oxidative stress
inflammatory response
high fat diet induced
stem cell transplantation
toll like receptor
type diabetes
metabolic syndrome
skeletal muscle
adipose tissue