Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention.
M SvendstrupK H AllinT I A SørensenT H HansenNiels GrarupTue Haldor HansenHenrik VestergaardPublished in: International journal of obesity (2005) (2017)
Our findings suggest that genetic variants influencing body fat distribution attenuate weight loss in women independently on the effect on WHR. The stronger effect of the GRSwomen implies heterogenic effects of the WHRadjBMI variants on weight loss. A strong effect of rs1358980-T in the VEGFA locus suggests that angiogenesis plays a role, but this needs confirmation from functional studies.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- polycystic ovary syndrome
- gastric bypass
- randomized controlled trial
- copy number
- pregnancy outcomes
- breast cancer risk
- cervical cancer screening
- endothelial cells
- glycemic control
- weight gain
- genome wide
- vascular endothelial growth factor
- body mass index
- insulin resistance
- metabolic syndrome