NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.

Naiara Santana-Codina Maria Quiles Del Rey Kevin S Kapner Huan Zhang Ajami Gikandi Callum Malcolm Clara Poupault Miljan Kuljanin Kristen M John Douglas E Biancur Brandon Chen Nupur K Das Kristen E Lowder Connor J Hennessey Wesley Huang Annan Yang Yatrik M Shah Jonathan Andrew Nowak Andrew J Aguirre Joseph D Mancias

Published in: Cancer discovery (2022)

Autophagy and iron metabolism are metabolic dependencies in PDAC. However, targeted therapies for these pathways are lacking. We identify NCOA4-mediated selective autophagy of ferritin ("ferritinophagy") as upregulated in PDAC. Ferritinophagy supports PDAC iron metabolism and thereby tumor progression and represents a new therapeutic target in PDAC. See related commentary by Jain and Amaravadi, p. 2023. See related article by Ravichandran et al., p. 2198. This article is highlighted in the In This Issue feature, p. 2007.

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