Safety and Effectiveness of Perioperative Hyperthermic Intraperitoneal Chemotherapy with Gemcitabine in Patients with Resected Pancreatic Ductal Adenocarcinoma: Clinical Trial EudraCT 2016-004298-41.

David Padilla-ValverdeRaquel Bodoque-VillarEsther García-SantosSusana SanchezCarmen Manzanares-Campillo Marta Rodriguez Lucia GonzálezAlfonso AmbrósJuana M CanoMaria Padilla-MarcoteFrancisco Javier RedondoJesus MartinLeticia Serrano-Oviedo

Published in: Cancers (2024)

The use of HIPEC with gemcitabine after surgery in patients with resectable pancreatic ductal adenocarcinoma reduces locoregional recurrence and may be associated with a significant decrease in pancreatic cancer stem cells.

Keyphrases

locally advanced
cancer stem cells
clinical trial
rectal cancer
squamous cell carcinoma
radiation therapy
randomized controlled trial
systematic review
patients undergoing
cardiac surgery
lymph node
study protocol
open label
phase ii
double blind
free survival
prognostic factors
phase iii
placebo controlled