Differential effect of high-frequency electroporation on myocardium vs. non-myocardial tissues.

Yonatan Moshkovits Dvora Grynberg Eyal Heller Leonid Maizels Elad Maor

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)

Electroporation effect is tissue-specific such that myocardium is more prone to electroporation damage compared with neural and vascular tissues. Our results suggest no neural or vascular damage with using a low-amplitude HF-IRE protocol. Further investigation is warranted to better identify other tissue-specific thresholds.

Keyphrases

high frequency
transcranial magnetic stimulation
gene expression
oxidative stress
randomized controlled trial
left ventricular
endoplasmic reticulum stress
heart failure