Login / Signup

NLRC5: new cancer buster?

Feng TangYadi XuBing Zhao
Published in: Molecular biology reports (2020)
Recent decades, there is significant progress in understanding the mechanisms of tumor progression and immune evasion. The newly discovered protein NLRC5 is demonstrated to participate in regulating cancer immune escape through enhancing MHC class I genes expression in certain tumors. Nevertheless, increasing evidence has revealed that NLRC5 is up-regulated in some other tumors and promote tumor development and progression. The purpose of this review is to describe the role of NLRC5 in tumors and discuss whether NLRC5 can be a potential target in cancer treatment.
Keyphrases
  • papillary thyroid
  • poor prognosis
  • squamous cell
  • transcription factor
  • squamous cell carcinoma
  • gene expression
  • single cell
  • risk assessment
  • long non coding rna
  • genome wide identification
  • bioinformatics analysis